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Early studies performed in the 1960s injected monomer and higher order molecular weight protein particulates of bovine gamma globulin into rodents

In the initial phase of the watermaze in which rodents search for the hidden platform, in each trial the rodent has only to bump into the platform once to locate it and escape

A recent study using 1 H-MRS demonstrated that intranasal administration of 200 mg of GSH significantly increased GSH levels in the dorsal putamen of patients with PD [107]

Similarly, a study focusing on CLOCK-related circadian regulators in nurses, found that hypermethylation in BMAL1 gene bodies was associated with working 3 consecutive NS per week, suggesting possible epigenetic silencing affecting CLOCK transcriptional activity