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Dehydration and electrolyte imbalances, which can occur secondary to reduced food and fluid intake or gastrointestinal side effects such as nausea and vomiting, may also contribute to these sensations

For severe deficiencies, daily or weekly infusions might be needed at first

The effectiveness of treatment will be analysed by examining the therapeutic success achieved in each arm at 8, 26 and 52 weeks, determining the 95% confidence interval for the percentage of patients in each treatment arm whose serum vitamin B12 concentrations become normalised

copper accumulation from GHK-Cu is the main driver of the off period