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Over the past decade, advances in the study of the biological roles of Mn have reshaped our understanding of its role in health and disease, with ongoing research continuously refining our understanding of its metabolic pathways and therapeutic implications 6,7

Topical application of PEPITEM not only reduced local inflammation but also had systemic effects, such as reducing disease-related splenomegaly and limiting the expansion of CD4+, CD8+, Th1, and Th17 T-cell populations in the spleen

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Accumulated Ang II is responsible for the overstimulation of its type-I receptor which is associated with various pathological conditions [16]