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Simultaneously, ROS activate PKC isoforms and the AGE-RAGE signaling cascade, which upregulate pro-inflammatory cytokines (TNF-, IL-6) and adhesion molecules (VCAM-1, ICAM-1) through NF-B activation (Gonzlez et al., 2023)

Thats actually down from previous recommendations from the Surgeon General, and the CDC, and American College of Sports Medicine, which recommended at least 30 minutes each day