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In the situation of substrate surplus, adipose tissue also switches from OXPHOS to Warburg/glycolysis developing hypertrophy (increased adipocyte size), hyperplasia (increased numbers of adipocytes), or both (Choe et al., 2016)

While B12 shots support metabolism, they are not a weight-loss treatment on their own

It is also given as a weekly injection, but that dual action may give extra support for some people, especially those with strong insulin resistance or a higher starting body weight

The peripheral neurotoxicity involves mitochondrial impairment, oxidative stress, and neuroinflammation, which can lead to axonal demyelination and sensory impairment [150]