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Histidine also has properties that protect against oxidative stress and may play a role in tissue repair [2]

This broad regulatory activity includes upregulation of tissue repair genes, collagen synthesis pathways, antioxidant defense systems, and anti-inflammatory signaling networks, alongside simultaneous downregulation of genes associated with tissue destruction, inflammation, and fibrosis

Sirtuins are reported to modulate numerous activities by controlling gene expression, DNA repair, metabolism, oxidative stress response, mitochondrial function, and biogenesis

Cytokine Modulation Pro-inflammatory cytokines like TNF-alpha, IL-6, and IL-1beta drive the inflammatory cascade that causes pain, swelling, and tissue damage