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In this model, moderate increases in pulmonary neutrophilia are expected and were indeed observed in IL-33-treated mice ( Figures 2I, J ), however the degree of increase in neutrophil populations was markedly lower in mice receiving melatonin +/- Luzindole alongside IL-33 ( Figures 2I, J )

Relationship between the Inhibition Constant (KI) and the Concentration of Inhibitor Which Causes 50 Per Cent Inhibition (I50) of an Enzymatic Reaction