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In vitro , we validated this increased gene expression via RT-qPCR and observed that BDG increases the global intracellular concentration of glutathione as well as the level of the oxidized glutathione (GSSG) form

Farzaneh F, Nadji SA, Khosravi D, Hosseini MS, Bahremani MH, Chehrazi M, Bagheri G, Sigaroodi A, Haghighatian Z

This leads to mitochondrial metabolic disorders, affecting ATP production, activating kinases to produce O 2 - , triggering oxidative stress, and further damaging mitochondria [204]