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The peptide's effects on fat metabolism also involve its insulin-like actions

In response to Cd exposure, cyclotide precursor mRNAs VbCP7S and its spliced variant VbCP6S were upregulated in the leaves, indicating a potential role in metal binding and detoxification (Zhang et al., 2009)

and hybrid receptors made of combinations of half IGF-1R and half insulin receptor isoforms or other receptor tyrosine kinases (18, 19) ( Figure 1 )

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