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Fangming Chen, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Second, mechanistic convergence in separate experiments is not the same as demonstrated synergy in a shared solution and a shared organism combining pro-angiogenic agents does not reliably multiply their effect, and uncontrolled angiogenesis is not an unambiguously good thing (the same vessel-forming signals that aid healing are, in other contexts, exactly what tumors exploit, which is why unsupervised pro-angiogenic stimulation is not casually assumed to be safe)