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Sometimes these medications are prescribed together under close medical supervision, but combining them can increase the risk of low blood pressure and slow heart rate

Currently, several chronomodulated therapies have proven their efficacy

Methylcobalamin should not be used in patients with early hereditary optic nerve atrophy (Lebers disease)

In addition to laboratory-scale evidence, further studies will be required to validate the performance of this mutant strain in large-scale industrial bioreactors