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Imbalance Between Oxidants and Antioxidant Systems in Asthma Homeostasis of cellular functions during oxidative stress depends on the appropriate induction of protective antioxidant mechanisms

doi: 10.1016/j.tifs.2022.04.010

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However, their clinical translation remains hampered by beyond-rule-of-five (bRo5) physicochemical liabilities, including high polarity, limited membrane permeability, and unpredictable pharmacokinetic behavior, which collectively lead to suboptimal bioavailability and risks of non-specific systemic distribution