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In a murine model of renal cell carcinoma, upregulation of G6PD and subsequent increase in NADPH was found to inhibit ferroptosis whereas G6PD knockdown in human hepatocellular carcinoma cells increased positive regulators of ferroptosis 83,84,85

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These side effects disappear as the body acclimates to the medicine

Context is critically important as regions around the globe consider whether supplementation with vitamin D alone or in combination with calcium would be beneficial