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Patients should seek urgent same-day assessment if they develop any new neurological symptoms, as subacute combined degeneration of the spinal cord a serious but preventable complication of prolonged B12 deficiency requires immediate treatment

Useful soft tissue endpoints include: muscle fibre organisation vascular response inflammatory marker panels collagen deposition fibroblast activity oxidative stress markers histology scoring cell migration These research areas overlap with tendon and ligament studies but focus more broadly on tissue integrity and repair-associated signalling