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Other aspects of TCA cycle function in brain are completed around postnatal day 15, indicated by maximum oxidative response in rat brain slices to stimuli at this age (Holtzman et al., in vivo by day 10 in barrel cortex (Melzer et al., In the absence of pyruvate carboxylase activity during early postnatal development (Figure 9) glutamate synthesis within the brain must be replaced by import of glutamate or a precursor

As the primary pathway for controlled protein turnover in eukaryotic cells, the UPS is crucial for maintaining the timing of circadian rhythms by regulating the stability of core clock proteins

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doi: 10.1002/tox.22405 63 ForoozanfardFSadatZ