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Sanchez V, Camarero J, O'Shea E, Green AR, Colado MI

242 The overexpression of indoleamine 2,3-dioxygenase 1 (IDO1) and TDO2 in GBM leads to the production of L-kynurenine, which interacts with the aryl hydrocarbon receptor (AHR) on TAMs, further inhibiting immune responses

GGT knockout mice experience increased accumulation of DNA oxidative damage, decreased intracellular GSH levels, elevated oxidative stress and death by 10 weeks of age due to cysteine deficiency (88)