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Animal studies in diet-induced obesity models show tesofensine treatment produces selective reduction in adiposity with improvements in insulin sensitivity, reductions in plasma lipids, and decreased accumulation of abdominal and subcutaneous fat mass

However, its benefits in terms of perioperative and long-term outcomes remain controversial

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Safety Profile Summary Favorable Safety: SS-31 has been evaluated in multiple clinical and preclinical studies, with findings showing a generally favorable safety profile