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These can be seen by putting a drop of fluid on a slide and examining it using a polarizing microscope, which takes advantage of the way uric acid crystals bend light

A pan-FGFR inhibitor, BGJ398 (Novartis), was prepared in an acetic acid buffer (pH 4.6) for 10 min, followed by mixing with PEG300 (50% of final volume) using vortex

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These results, in addition to the mRNA findings, underscore the improved availability of antioxidants that occurred with ALA treatment