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Cancer cells can selectively be targeted by hypoxia-triggered mechanism because they are found to possess lower oxygen concentration of ~0.022% as compared to normal cells with oxygen concentration of ~29%

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Formation and maintenance of the BBB

S-JS: Visualization, Writing original draft

The release of Dox from RS liposomes in the TME through the DDA link fracture triggered by ROS or glutathione is seemingly the prerequisite for the formulations to exert their therapeutic action