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Cunningham et al., 2002

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In one study, they found that oral administration of 300 milligrams of glutathione over four months in addition to lifestyle changes improved nonalcoholic fatty liver disease

Beyond lowering blood sugar, metformin may also: Cause weight loss Help manage polycystic ovarian syndrome (PCOS) symptoms Improve insulin sensitivity Manage gestational diabetes Manage prediabetes So, while berberine may be an option for someone who prefers not to take prescription medication or cannot tolerate them, metformin remains the more effective, safe and proven choice