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Additionally, BH4 is involved in CoQ10 synthesis, an important lipophilic antioxidant that captures and neutralizes lipid peroxidation radicals, protecting membrane phospholipids, especially those with two PUFA tails, from oxidative degradation (Gu et al., 2023)

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MBGS was assessed for its ability to detect CTNNB1 mutation and IO response in integrated RNA/whole-exome-seq and spatial transcriptomic data from multiple HCC patient cohorts