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However, factors such as stress, an unhealthy diet, excessive alcohol, antibiotics, and drug consumption can compromise the composition of the intestinal microbiota and the homeostasis of the intestinal barrier function of the intestine, leading to increased intestinal permeability

Once the damaged elements, known as free radicals, approach the membrane surrounding the spermatozoa, the quality of the sperm is compromised, as well as fertility

Archived from the original on May 4, 2008

For example, NAMPT expression changes during diseases such as cancer, diabetes, and fatty liver disease 211 , and eNAMPT levels decrease with age 328