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doi: 10.1016/S0140-6736(15)01156-3 132

Headache disorders affect about 50% of the global population, or roughly 4 billion people, as of 2024 estimates

Nanoparticle Drug Delivery Technology Can Cross the Blood-Brain Barrier A Japanese research team has developed a cyclic peptide (a chain of amino acids bonded circularly) that enhances blood-brain barrier (BBB) penetration