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Preclinical evidence shows that polyphenols exert greater selectivity in tumor cells to target oxidative phosphorylation and regulation of the mitochondrial membrane potential (MMP), glycolysis, pro-oxidant pathways, and antioxidant (adaptive) stress responses and their anticancer efficacy relates to the protonophoric and pro-oxidant properties rather than the specific effects on downstream molecular targets affected by MMP dissipation and mitochondrial uncoupling [43]

Free Radical Biol Med 52:781793 Camargo MMP, Martinez CBR (2006) Biochemical and physiological biomarkers in Prochilodus lineatus submitted to in situ tests in an urban stream in southern Brazil

Hyperandrogenemia and insulin resistance: the chief culprit of polycystic ovary syndrome

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