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Iran J Basic Med Sci (2018) 21:181

Currently, clinicians divide patients into at-risk groups to ensure targeted plans for diagnosis, prophylactic treatment, and pre-emptive therapies

Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism

These observations emphasize that PPAR manipulation exerts context-dependent effects on ferroptosis and underscore the importance of the lipid microenvironment in shaping ferroptotic sensitivity