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This condition results in chronic pelvic pain, infertility, and adversely impacts the overall quality of life for affected women ( Many factors may contribute to EMS development, including retrograde menstruation, modulation of metabolic pathways and the endocrine system, epithelial-mesenchymal transition, as well as altered immunity, inflammation, and redox balance ( Evodiamine (EDM), a natural alkaloid ingredient with a quinazolinocarboline skeleton structure, can be extracted from the fruit of Evodiae rutaecarpa ( In our earlier research, we identified an association between endometriosis and ER upregulation, leading to the initiation of endometriosis development ( in vitro cell culture study