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We thus predicted that R503 and D504 in human MAST4 constitute the RD motif, K506 is the proximate lysine residue, D522/F523/G524 is the DFG motif, and T534 or T535 is the autophosphorylation site (Fig 4A)

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Inhibition of proliferation and induction of apoptosis Following DNA damage, the cell cycle can be transiently arrested to allow for DNA repair or for activation of pathways leading to programmed cell death (apoptosis) if the damage is irreparable (40)

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