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Their secretion of matrix metalloproteinases (MMPs), serine proteases, and cathepsins disrupts the endothelial basement membranes, degrades extracellular matrix components, including collagen, and facilitates the migration of tumor and stromal cells, ultimately promoting tumor angiogenesis and metastasis ( Dixon defined ferroptosis as a unique type of controlled cell death in 2012, based on its iron-dependent mechanism and fundamental deviations from apoptotic pathways ( Figure 3 )

Loren Pickart, who noticed that older blood lost its ability to stimulate tissue repair compared to younger blood and traced the difference back to this small peptide-copper complex

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NGF restores decrease in catalase and increases glutathione peroxidase activity in the brain of aged rats