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Some signs and symptoms of Vitamin B12 deficiency include jaundice, weakness, fatigue, mouth ulcers, dizziness, disturbed vision, etc.

Additionally, in human and murine IBD models, upregulated ferroptosis-related gene expression and elevated malondialdehyde (MDA) levels confirm the association between ferroptosis and UC (68)

Thrombin participates in the multiple processes of inflammatory cascade reactions, and thus, coagulase inhibitors might be useful for IRI treatment because they reduce the neutrophilendothelial interaction mediated by coagulase (Iba et al., 2024)

It also supports the production of sex hormone binding globulin (SHBG), which binds to testosterone in the blood and reduces its activity