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Furthermore, long-term therapy, in contrast to short-term treatment, generates various types of RONS in different amounts

doi: 10.3390/nu13030886 42

And, even if we don't take supplements, if we eat a diet rich in folate (fruits, vegetables, legumes, nuts...), it is possible to avoid the folate trap (this does not always happen, but it is common)

For example, DNMTIs are most effective in hematological diseases such as myelodysplastic syndromes, whereas treatment success in solid tumors is limited (Gurion et al., 2010)