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We utilized RNA sequencing, bioinformatic approaches, and both in vivo and in vitro experiments to confirm that TMAO promotes cholelithiasis by dysregulating hepatic cholesterol metabolism through its effects on the key regulatory genes apolipoprotein A4 ( APOA4) and proprotein convertase subtilisin/kexin type 9 ( PCSK9 )

Koeth RA, Levison BS, Culley MK, Buffa JA, Wang Z, Gregory JC, Org E, Wu Y, Smith JD LL, et al

WO03047563 describes the use of propionyl L-carnitine, alone or in combination with sildenafil, for the treatment of erectile dysfunction

Anticonvulsants for neuropathic pain syndromes: mechanisms of action and place in therapy