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Copper ion load from AHK-Cu remains well below toxic thresholds even at 2mg daily, but chronic use beyond 6 months lacks human safety data as of 2026

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In an alkali-burn rat model with companion HUVEC work, Huang and colleagues reported that BPC-157 upregulated VEGF-A expression in wounded skin and accelerated tube formation in vitro, attributing effects to ERK1/2 signaling a pathway-level overlap but not an exact replication of the VEGFR2-internalization finding (Huang et al., 2015)

[DOI] [PubMed] [Google Scholar] 69.Nabavi SF, Daglia M, Moghaddam AH, Habtemariam S, Nabavi SM