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This condition, termed Hypothalamic Syndrome (HS), encompasses a spectrum of symptoms, including hypothalamic obesity (characterized by rapid, uncontrollable weight gain despite caloric restrictions), disordered eating behaviours (uncontrollable hyperphagia, insatiable hunger, food-seeking behaviour), neurocognitive and behavioral changes (memory deficits, emotional lability, depression), sleep disturbances (hypersomnia, narcolepsy, circadian rhythm disruption), fatigue, and autonomic dysfunction (imbalances in body temperature, thirst, heart rate, and blood pressure regulation) [85, 86]

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The impact of lorcaserin in patients with T2DM and BMI: 27-45kg/m 2 was examined in the BLOOM-DM trial which showed a reduction of body weight by approximately 5kg versus 1.6kg in the placebo group, as well as significant decreases in heart rate, HDL levels, and waist circumference