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In ovarian cancer, tumor cell-derived exosomes carrying CMTM4 are taken up by macrophages, promoting TGF-1 and CXCL12 secretion via NF-B pathway activation and enhancing ICAM1/CD206-mediated M2 polarization, thereby reducing the efficacy of PD-1 inhibitors (203)

This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Subscribe to this journal Receive 12 digital issues and online access to articles $119.00 per year only $9.92 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout References Park, W