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In this process, the over-consumed platelets and coagulation factors lead to the reduction of coagulation activity, further imbalance of coagulation and anticoagulation, secondary hyperfibrinolysis, and the release of a large number of plasminogen activators, eventually leaded to disseminated intravascular coagulation (DIC), which appeared in most COVID-19 patients

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Gastrointestinal studies employ chemically induced lesion models (cysteamine, indomethacin, alcohol) in rats, with BPC-157 administered before or after injury