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To analyze region-specific transcriptome profiles of patients with GBM, we obtained fragments per kilobase of transcripts per million mapped reads data from the Ivy glioblastoma atlas project (Ivy GAP) website ( Regional information was divided into seven types: hyperplastic blood vessels in the cellular tumor (n=22), microvascular proliferation (n=28), leading-edge (n=19), infiltrating tumor (n=24), cellular tumor (n=111), perinecrotic zone (n=26), and pseudopalisading cells around necrosis (n=40)

Following [ 35 S]methionine labelling, serum metabolites from mice with TR/GR-null livers showed a labelled species that migrated as GSSG in TLC, which was much less abundant in serum of control mice (Fig

These tend to be most pronounced during the dose escalation period and generally improve over time