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The probe consists of three segments: a phenol head group (CoQ 10 -like head group), a reporter (fluorescent dye), and a lipophilic segment (9 units isoprenyl group)

SIRT5 is a highly efficient protein lysine desuccinylase, and has been shown to participates in carcinogenic process through desuccinylating multiple targets, such as mitochondrial malic enzyme 2 (ME2) [36], pyruvate kinase M2 (PKM2) [37], serine hydroxymethyltransferase 2 (SHMT2) [38], etc

Srejovic I, Selakovic D, Jovicic N, Jakovljevic V, Lukic ML, Rosic G (2020) Galectin-3: roles in neurodevelopment, neuroinflammation, and behavior

doi: 10.1016/j.ejphar.2024.177107 18 BrownR