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The probable etiologies for the vitamin B 12 deficiencies in the patients without a history of gastrectomy were gastritis, diabetes medications, a vegetarian diet, antibodies to the intrinsic factor, and early gastric cancer

High levels of lipid peroxidation-derived aldehydes, including 4-hydroxy-nonenal (4-HNE) and malondialdehyde (MDA) [92], protein glycoxidation markers such as pentosidine [93], and stress-induced DNA damage molecules, more specifically 8-hydroxy-2-deoxyguanosine (8-OHdG) [94, 95], have also been revealed in the spinal cord from sALS patients

Hartl J, Ehlken H, Sebode M, Peiseler M, Krech T, Zenouzi R