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P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain

Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

When tumor cells are detached from the ECM, glucose metabolism and mitochondrial respiration are inhibited, leading to reduced cellular energy synthesis and increased intracellular ROS levels, indicating the important role of ECM adhesion in cellular metabolism (125)