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A systematic review of nine clinical trials with 469 patients found that curcumin significantly reduced ulcer size, pain intensity, and sometimes the number of ulcers, especially when applied as a gel, paste, or mouthrinse (Al-Maweri et al., 2022)

Hou, D., Yousaf, L., Xue, Y., Hu, J., Wu, J., Hu, X., Feng, N., & Shen, Q

doi: 10.1016/j.celrep.2015.02.041 84 DasguptaBYiYChenDYWeberJDGutmannDH

Disease progression of IA is credited to the function of T cell adaptive immunity marked by dysregulated production of Th (T-helper cell) cell cytokines (176, 177)