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for instance, there are no reports of NAD+ altering the metabolism of prescription medications or diminishing their efficacy

82,83 Patients may also experience paresthesia and allodynia, where non-painful stimuli are perceived as painful

However, some comparative studies in animals suggest that oral ingestion of the peptide can also have systemic effects

176 It noted that whilst formularies identify vitamin B 12 deficiency as a possible side effect of metformin, there is a lack of guidance relating to the investigation of the risk, despite there being a deficiency prevalence of 17% in the study cited in the editorial