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Lum AF, Wun T, Staunton D, Simon SI (2004) Inflammatory potential of neutrophils detected in sickle cell disease

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In fact, they initially adopt a proinflammatory phenotype and then later they acquire an anti-inflammatory profile to repair the tissue damage ( in vivo setting cannot be recapitulated by the static vision of M1-M2 polarization adopted in in vitro experiments, reached by stimulation with lipopolysaccharide (LPS)/interferon- (IFN-) or Interleukin (IL)-4/IL-13 or IL-10, respectively ( Reactive oxygen species (ROS) have been known for many years as fundamental for macrophages to kill invasive microorganisms through the oxidative burst mediated by NADPH oxidase ( Oxygen is a highly electronegative element that readily accepts electrons generated by normal oxidative metabolism within cells, thereby producing ROS