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J Clin Invest 125 (6): 22932306

A major cause of shoulder pain is rotator cuff tendinitis, also called impingement syndrome

These cells are also specialized to recognize bacterial-derived molecules, known as prokaryotic-associated molecular patterns, with the help of the Toll-like receptors on the cell surface and the nucleotide-binding oligomerization domain-like receptors in the cytoplasm, which activate defense mechanisms by the secretion of anti-microbial peptides 2

Different senolytic agents act through distinct molecular mechanisms, including: Inhibition of Anti-Apoptotic Pathways: The BCL-2 family regulates apoptosis, and senescent cells often exhibit increased expression of anti-apoptotic (pro-survival proteins) proteins such as BCL-2, BCL-XL, and BCL-W