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For xenograft studies, animals were allocated into groups ensuring the mean, median and standard error of tumor size was similar across all groups

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Published studies in rodents report that oral acetaminophen treatment of male animals at doses that are 1.2 times the MHDD and greater (based on a body surface comparison) result in decreased testicular weights, reduced spermatogenesis, reduced fertility, and reduced implantation sites in females given the same doses