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Furthermore, oxidized cardiolipin acts synergistically with Ca to promote the opening of the mitochondrial permeability transition pore (MPTP), leading to proton leakage and MMP collapse [38,39,40]

Despite of various outcomes reported in vitro and in animal models, some studies are concentrated to humans and the results obtained are represented below in Table

A recent study showed that GPX1 can also localize in the nucleus of prostate epithelial cells, although its specific biological function in this location remains unknown [162]

This phenomenon, whereby a kinase recognizes an already phosphorylated residue in the substrate, can serve as a mechanism for signal integration, amplification and cross-talk