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Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

Some people might experience mild side effects like dizziness or nausea during or immediately after the treatment

Furthermore, the low efficacy of therapy, the limitations of the mechanisms of available drugs, and the development of more personalized treatment strategies requires further research and improvements [31]

456,457,458 The primary advantage of covalent conjugation is that the resulting product is a single compound with defined structural and stoichiometric characteristics, aligning with the ideal properties for drug design and in vivo application