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PCC plays a crucial role in the propionic acid metabolic pathway by converting propionic acid and its precursors (valine, isoleucine, threonine, methionine, and the cholesterol side chain of odd-chain fatty acids) into propionyl CoA (Fig

1 Despite the availability of multiple treatments, a substantial proportion of patients either fail to achieve remission, particularly in cases of treatment-resistant depression (TRD) and late-life depression