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Among the most effective candidates are transferrin receptor ligands, lactoferrin, Angiopep-2, apolipoproteins, and glutathione-based systems

GHK-Cu (glycyl-L-histidyl-L-lysine copper) has been studied in clinical settings for decades, and the safety data is strong

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Overall, these findings underscore the complexity of the molecular interactions with the neural circuitry underlying anxiety and highlight the necessity for a multifaceted approach in the design of anxiolytic treatments