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doi: 10.1016/j.diff.2019.10.008 18 GustafsonMLDonahoePK

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Heterogeneity of human ALI/ARDS Large epidemiology studies on ALI patients found that clinical risk factors of intrapulmonary origins, such as pneumonia, lung contusion, and aspiration, etc., account for the majority of ALI causes (up to ~ 80%), while those of extrapulmonary origin, such as non-pulmonary sepsis and non-cardiogenic shock, account for a small portion [84]