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Indeed, the ultrastructural hallmark of classical EDS is a 25% increase in fibril diameter and rare composite fibrils, often called collagen cauliflowers (Figure 2c)

104 Medications such as cyclosporine A, bosentan, oral contraceptives, and cyclosporine have been reported to inhibit ABC transporter BSEP or MDR3 function and lead to cholestatic patterns that present as drug-induced liver injury